Treatment Options: Oral Medications


MSMonday: Treatment Options: Oral Medications 

Last week we discussed inject-able medications. This week let’s discuss the oral medication options that are available. Oral medications didn’t hit the market until just recently. Before then, people with MS were stuck with injection only options, which was clearly not ideal. As patients, we would hear about oral medications being an option someday in the future, but we didn’t know when it would actually happen. Until it eventually did in 2010 when Gilenya was approved by the FDA. Currently there are only three oral medications on the market approved for relapsing remitting MS. Let’s take a closer look at each of these medications.

Gilenya

Gilenya is in a new class of medication called sphingosine 1-phosphate receptor modulator (that’s a mouthful). Scientist think that it works by keeping certain white blood cells in the lymph nodes, thereby making it impossible for them to cross the blood brain barrier and get into the central nervous system. Making it so the cells cannot get into the central nervous system, reduces inflammation and damage to nerve cells. In several studies done, Gilenya was shown to be effective. Gilenya cut relapses by 52% when compared to Avonex in a one year study. It also prevented relapses by 54% when compared to placebo over a two year period. The FDA approved the use of Gilenya in 2010 for relapsing remitting MS.
There are several side effects associated with Gilenya. Headache, slowed heart beat, weakness, fatigue, infection, elevated liver enzyme’s and diarrhea were noted. An uncommon side effect is macular edema, which is the swelling of an area of the retina which is responsible for central vision. Gilenya is also known to slow the heart rate significantly, especially in the first month of treatment. An individual also might feel really tired, have heart palpitations or chest pain or feel dizzy. Usually if someone experiences the symptoms, they will disappear within the first day or two of treatment.
In 2012 the FDA updated the regulations around a patient’s first dose of Gilenya. It is now required that an individual have an ECG before receiving the first dose and again six hours after the first dose. Is also recommended that the first dose be taken under medical observation. This is due to a patient unfortunately passing away in late 2011 after taking their first dose of Gilenya. As far as I know, the has not been definitively linked to Gilenya.

Tecfidera

Tecfidera, also known as dimethyl fumarate, is an oral medication taken twice a day that was specifically developed for people with relapsing remitting MS. A similar chemical compound called Fumaderm, has been used in Germany for many years to treat flares of psoriasis. The specific way Tecfidera works is still unknown, but scientist think that it activates certain pathways in the body that help to protect nerve cells from damage and inflammation. In one study, in a two year period 27% of people who are taking Tecfidera experience a relapse compared to 46% of people in the placebo group. Tecfidera was approved by the FDA in 2014 for the use in relapsing remitting MS.
Common side effects of Tecfidera  include flushing, stomach pain, nausea and diarrhea. Side effects seem to be present more so at the beginning of treatment, and then will dissipate as treatment progresses. There have been cases of PML reported in patients who are taking Tecfidera, 4 of them actually. PML is a rare and deadly brain disease that can happen when individual is taking an immuno-suppressant medication. In order to develop PML, individual must be positive for the JC virus first. Routine blood test to monitor JC virus status is recommended when taking most MS meds.

Aubagio

Aubagio, also known as teriflunomide, is a pyrimidine synthesis inhibitor. It works by reducing the number of white blood cells in the central nervous system, decreasing inflammation overall and protecting nerves in people with MS. In several studies, Aubagio was proven to be effective over placebo, reducing relapses by 31%, reducing disability progression by 30% and showing an 80% decrease in brain lesions. Aubagio was approved in 2012 by the FDA for use in relapsing remitting MS.
Common side effects of Aubagio include headache, nausea, hair loss, diarrhea, elevated liver tests, like symptoms and numbness or tingling in in the hands or feet. Less common but more serious side effects include elevated blood pressure, increased risk for infections and liver damage. While taking Aubagio  you will need to have regular blood test to monitor liver function and blood cell counts. Aubagio is also associated with severe birth defects, and neither women nor man should be taking Aubagio if pregnancy as planned. Aubagio can remain in your body for up to two years after discontinuing the medication, so a special treatment may be needed to remove the drug from your system if you’re planning on becoming pregnant. Usually when taking the medication, it is required that an individual be on an effective birth control method.
I took Aubagio for about a year. Unfortunately I went into the treatment already in a “active disease state “, and had two relapses while taking the medication. I liked how I could just take a pill instead of the daily injections of my previous Copaxone, but I soon experienced side effects of (a lot of) hair loss and irregular blood cell counts. Due to the relapses, I eventually changed medications. 
The arrival of oral medications has been a welcome relief for many MS patients. They represent the constant advancement of research and development. Hopefully the future will bring many more options to the table.

I’M ALISSA!

I help women who have also been diagnosed with Multiple Sclerosis make specific and personalized diet, lifestyle & subconscious changes so that they can begin to heal their body, reduce disease symptoms, and return to a life they love.hey there,

follow along on Instagram:

In case you needed to hear that today.

You’re not a failure.
You didn’t “fail” at healing.
Having MS is hard- do what’s best for you.

In case you needed to hear that today.

You’re not a failure.
You didn’t “fail” at healing.
Having MS is hard- do what’s best for you.
...

58 9
This is my challenge to you over the next week.

Take some time and think about this past year.

All you’re proud of, all you’ve accomplished. And if you have some things that don’t bring you joy, be proud of yourself for making it through in one piece and still being here.

Reflection is a great way to cultivate motivation to keep going..

You’re doing amazing.
You’ve done amazing.
Let’s keep going.
🧡❤️🧡

This is my challenge to you over the next week.

Take some time and think about this past year.

All you’re proud of, all you’ve accomplished. And if you have some things that don’t bring you joy, be proud of yourself for making it through in one piece and still being here.

Reflection is a great way to cultivate motivation to keep going..

You’re doing amazing.
You’ve done amazing.
Let’s keep going.
🧡❤️🧡
...

21 4
Comparison is the thief of joy.

Regardless of what you see others doing,
you’re right where you should be.

❤️🧡❤️

Comparison is the thief of joy.

Regardless of what you see others doing,
you’re right where you should be.

❤️🧡❤️
...

24 10
This took me completely by surprise, cause I usually roast myself after a simple mistake 🙈

But, I just didn’t? 🤷🏻‍♀️

Working on self improvement is weird.
Like I’m not even consciously working on how I talk to myself at the moment. 

Have I in the past? Sure. And it’s something I try to stay conscious of, but def have my moments where I fall into old patterns.

But this moment gave me hope.

What moments in your journey have given you hope lately?

This took me completely by surprise, cause I usually roast myself after a simple mistake 🙈

But, I just didn’t? 🤷🏻‍♀️

Working on self improvement is weird.
Like I’m not even consciously working on how I talk to myself at the moment.

Have I in the past? Sure. And it’s something I try to stay conscious of, but def have my moments where I fall into old patterns.

But this moment gave me hope.

What moments in your journey have given you hope lately?
...

55 2
Thank you for supporting my business this past year. 

Because in reality, you’re supporting me.

So thank you.
Scott thanks you too!

Thank you for supporting my business this past year.

Because in reality, you’re supporting me.

So thank you.
Scott thanks you too!
...

38 7
👉🏼Feeling stuck with your MS symptoms?
👉🏼Feeling like your body betrayed you and is working against you?
👉🏼Are you worried you’re stuck like this and will never get better?

I get it. At one point I did too.

Years ago I was experiencing “Aggressive MS” and I thought I’d never function the same.

I thought my days of moving how I wanted, or doing anything on a whim were over.

I couldn’t walk well, couldn’t feel my body correctly and I was SCARED.

But now?
I’m confident in the ways I’m helping myself.
I no longer have aggressive MS.
I can move how I want, when I want.

Because of the changes I’ve made over the years.

No, it’s not easy, but that’s where I come in!!

I’ve dedicated my life to helping those with MS realize that feeling better is possible and helping them get there.

My 2 courses and my membership are on sale this weekend for Black Friday,

want to start your own success story??

Comment SUCCESS below and I’ll send you the link!!

👉🏼Feeling stuck with your MS symptoms?
👉🏼Feeling like your body betrayed you and is working against you?
👉🏼Are you worried you’re stuck like this and will never get better?

I get it. At one point I did too.

Years ago I was experiencing “Aggressive MS” and I thought I’d never function the same.

I thought my days of moving how I wanted, or doing anything on a whim were over.

I couldn’t walk well, couldn’t feel my body correctly and I was SCARED.

But now?
I’m confident in the ways I’m helping myself.
I no longer have aggressive MS.
I can move how I want, when I want.

Because of the changes I’ve made over the years.

No, it’s not easy, but that’s where I come in!!

I’ve dedicated my life to helping those with MS realize that feeling better is possible and helping them get there.

My 2 courses and my membership are on sale this weekend for Black Friday,

want to start your own success story??

Comment SUCCESS below and I’ll send you the link!!
...

16 0
Grab your path to healing!!

These are the lowest prices for my courses like ever, and they won’t be back. (And they’ll prob be going up in the new year- planning some updates!!)

Comment HEALING below and I’ll send you a link, or check out my stories!!

Grab your path to healing!!

These are the lowest prices for my courses like ever, and they won’t be back. (And they’ll prob be going up in the new year- planning some updates!!)

Comment HEALING below and I’ll send you a link, or check out my stories!!
...

3 2
The first step to being successful with managing stress (& being successful with anything really) is:

Awareness of where you currently are.

You can’t change or manage what you’re not aware of.

You can only know yourself as deep as you’re awareness of yourself goes.

Try this:
Right now as you read this, pause for a sec.
Take a deep breath, and ask yourself:

Where were my thoughts?
Where is my breathing?
What am I saying to myself?

Get really honest here too (warning- it might be uncomfy)

What did you discover while checking in? Let me know in the comments!

-
-
If we haven’t met yet, Hi! 👋🏼👋🏼 I’m Alissa. I’m a Holistic Practitioner & Therapist specializing in MS. 
I use all the tools I’ve comprised over my 10+ year career (and 14+ years with MS) to help my clients with MS decrease their symptoms, improve their overall health and get back to living life on their terms, not MS’ terms.
Interested to hear how that might look for you? Comment 🧡 below or DM me and we’ll chat!

The first step to being successful with managing stress (& being successful with anything really) is:

Awareness of where you currently are.

You can’t change or manage what you’re not aware of.

You can only know yourself as deep as you’re awareness of yourself goes.

Try this:
Right now as you read this, pause for a sec.
Take a deep breath, and ask yourself:

Where were my thoughts?
Where is my breathing?
What am I saying to myself?

Get really honest here too (warning- it might be uncomfy)

What did you discover while checking in? Let me know in the comments!

-
-
If we haven’t met yet, Hi! 👋🏼👋🏼 I’m Alissa. I’m a Holistic Practitioner & Therapist specializing in MS.
I use all the tools I’ve comprised over my 10+ year career (and 14+ years with MS) to help my clients with MS decrease their symptoms, improve their overall health and get back to living life on their terms, not MS’ terms.
Interested to hear how that might look for you? Comment 🧡 below or DM me and we’ll chat!
...

14 1
Progress is absolutely not linear.

But, it’s still progress nonetheless.

I see you if you’re in a “dip” or feel like you’re going “backwards”

You’re really not, you’re right where you should be.

Keep going!!
🧡❤️🧡

Progress is absolutely not linear.

But, it’s still progress nonetheless.

I see you if you’re in a “dip” or feel like you’re going “backwards”

You’re really not, you’re right where you should be.

Keep going!!
🧡❤️🧡
...

22 1
Lol, all this got me was an MS diagnosis. 

This was me basically my whole life up until a few years ago.

My clients have all talked about situations like this too.

It’s no wonder why a lot of us have an autoimmune disease now. 

Please, speak your truth. Your body will thank you.

If we haven’t met yet, Hi! 👋🏼👋🏼 I’m Alissa.
I’m a Holistic Practitioner & Therapist specializing in MS.

I use all the tools I’ve comprised over my 10+ year career (and 14+ years with MS) to help my clients with MS decrease their symptoms, improve their overall health and get back to living life on their terms, not MS’ terms.

Interested to hear how that might look for you? Comment 🧡 below or DM me and we’ll chat!

Lol, all this got me was an MS diagnosis.

This was me basically my whole life up until a few years ago.

My clients have all talked about situations like this too.

It’s no wonder why a lot of us have an autoimmune disease now.

Please, speak your truth. Your body will thank you.

If we haven’t met yet, Hi! 👋🏼👋🏼 I’m Alissa.
I’m a Holistic Practitioner & Therapist specializing in MS.

I use all the tools I’ve comprised over my 10+ year career (and 14+ years with MS) to help my clients with MS decrease their symptoms, improve their overall health and get back to living life on their terms, not MS’ terms.

Interested to hear how that might look for you? Comment 🧡 below or DM me and we’ll chat!
...

90 4
This has been a TOUGH week friends.

Don’t lose yourself.

What else would you add to this list?
What helps you when life is super hard?

❤️❤️

This has been a TOUGH week friends.

Don’t lose yourself.

What else would you add to this list?
What helps you when life is super hard?

❤️❤️
...

20 2
I’ve been actively working on my nervous system for the past year or two.

That hasn’t meant that all my anxiety or depression magically vanished.

It just means that when I do find myself feeling like an anxious mess or a depressed puddle, I know how to attend to and care for myself.

Not in the goal of “fixing” per se, more honoring and accepting.

This is one of the ways I help my clients improve their MS symptoms, but attending to their nervous systems and improving their stress response and resilience.

I have so many ways to work with me.. from 1:1 support to my free community.. comment below “interested” and we’ll chat about what would be right for you!

I’ve been actively working on my nervous system for the past year or two.

That hasn’t meant that all my anxiety or depression magically vanished.

It just means that when I do find myself feeling like an anxious mess or a depressed puddle, I know how to attend to and care for myself.

Not in the goal of “fixing” per se, more honoring and accepting.

This is one of the ways I help my clients improve their MS symptoms, but attending to their nervous systems and improving their stress response and resilience.

I have so many ways to work with me.. from 1:1 support to my free community.. comment below “interested” and we’ll chat about what would be right for you!
...

18 2

As Featured In:

© LISSMS 2024 | Powered By TheDevQ

0
Your Cart
Your cart is emptyReturn to Shop
Calculate Shipping
Apply Coupon