Treatment Options: Medications in the Pipeline


New Medications in the Pipeline

For the past three weeks we have looked at the different categories of medications available for multiple sclerosis, injectable medications, oral medications and infused medications. This week we will take a look at the medications that are up-and-coming in the research pipeline. There are numerous studies going on currently, far too many to list all of them in one post, but we will look at some of the biggest studies going on right now.

Laquinimod

Laquinimod is a oral medication that is currently in phase 2 and phase 3 clinical trials. In 2014 it was refused a license for relapsing remitting MS due to poor trial results. It is now being studied for both relapsing remitting and primary progressive MS.
Laquinimod is thought to alter behavior of a me in cells and preventing them from crossing the blood brain barrier and damaging myelin. It also looks like Laquinimod can reduce inflammation and protect nerve structures and functions.
Several studies over the past few years were not promising. The drug did not reduce the relapse rate as compared to a placebo, but it did reduce rates of brain shrinkage and disability progression.

Ofatumumab

Ofatumumab is an injection or an infusion that is being researched for relapsing MS. Phase 2 trials were completed and now Phase 3 trials have begun. In these phase 3 trials the medication is injected under the skin every four weeks. Ofatumumab is an antibody and is thought to work by binding to the surface of a specific immune cell, B cells, and reduce their numbers.
In past clinical trials the results were very promising. Ofatumumab reduced relapse rates and slowed worsening of disability more effectively than Aubagio and Ofatumumab reduced new brain lesions by up to 90% as compared with placebos.

HSCT

HSCT is an intense chemotherapy treatment for multiple sclerosis, it is also known as stem cell treatment. It works by removing harmful immune cells then the individuals own stem cells are used to regrow the immune system.
There are several clinical trials that are going on using stem cell treatment for MS. Usually the individuals involved in these trials have had disease progression despite being on medication previously.
Results have been generally promising and showed that stem cell therapy has been effective at reducing relapses. Several studies also showed that stem cell therapy has been able to reduce disease progression as evidenced by improved EDSS scores.
There are over a hundred clinical trials currently going on looking for new treatments for Multiple Sclerosis and it’s related symptoms. Various studies include “Pilot study of Mirabegron and behavioral modification including pelvic floor exercise for overactive bladder in multiple sclerosis (MIRROR)” which is in Phase 4 and “A Multiple Dose Study of ABT-555 in Subjects With Relapsing Forms of Multiple Sclerosis” which is in Phase 1.
It is an exciting time in MS research. Hopefully more treatments that look at gut flora and the effects it has on MS progression will be completed soon as well!

I’M ALISSA!

I help women who have also been diagnosed with Multiple Sclerosis make specific and personalized diet, lifestyle & subconscious changes so that they can begin to heal their body, reduce disease symptoms, and return to a life they love.hey there,

follow along on Instagram:

What she also didn’t know?
The MS diagnosis would be the best thing to happen to her

Ok maybe not best lol, but I now can see what a gift it was.

You see, the MS diagnosis I got eventually gave me a reckoning moment with my health.

Change something, or else this is gonna go downhill fast.
This being my body, my ability to move, to live doing the things I want to do.

And man did it help.

I went from “aggressive MS” to not even thinking about MS on some days.

This process I went through? That’s exactly what I help others with now.

I currently have 2 Individual Client spots open!! (1 might be gone soon though..)

We can work on..
✨How you’re feeling mentally & emotionally about your MS diagnosis.
✨Strategies to mitigate your symptoms, that include nutrition, movement and cognitive/emotional methods
✨Anything else your body needs 

Interested in what this would look like for you?
Comment 🧡🧡 below and I’ll send you details!!

#lissms #multiplesclerosis #nervoussystemregulation #thisisms #becausems #multiplesclerosiswarrior #multiplesclerosissupport

What she also didn’t know?
The MS diagnosis would be the best thing to happen to her

Ok maybe not best lol, but I now can see what a gift it was.

You see, the MS diagnosis I got eventually gave me a reckoning moment with my health.

Change something, or else this is gonna go downhill fast.
This being my body, my ability to move, to live doing the things I want to do.

And man did it help.

I went from “aggressive MS” to not even thinking about MS on some days.

This process I went through? That’s exactly what I help others with now.

I currently have 2 Individual Client spots open!! (1 might be gone soon though..)

We can work on..
✨How you’re feeling mentally & emotionally about your MS diagnosis.
✨Strategies to mitigate your symptoms, that include nutrition, movement and cognitive/emotional methods
✨Anything else your body needs

Interested in what this would look like for you?
Comment 🧡🧡 below and I’ll send you details!!

#lissms #multiplesclerosis #nervoussystemregulation #thisisms #becausems #multiplesclerosiswarrior #multiplesclerosissupport
...

24 2
First..
Save this reel so you can come back to it and send it to a bestie so they can feel better too!!

Now.. how do you feel after taking that breath?

A little more calm, centered and focused?
Probably.

How we breathe is such a huge piece of the nervous system regulation puzzle, this well def help in your efforts.

Give it a try a few times a day, and let me know what you notice!!

If we haven’t met yet, Hi! 👋🏼👋🏼 I’m Alissa.

I’m a Holistic Practitioner & Therapist specializing in MS. 
I use all the tools I’ve comprised over my 10+ year career (and 15+ years with MS) to help my clients decrease their symptoms, improve their overall health and get back to living life on their terms, not MS’ terms.

I currently have 2 Individual Coaching spots open!! (if you live in MA I take some insurance!!)
Comment 🧡 below to learn more!!

#lissms #multiplesclerosis #nervoussystemregulation #becausems #thisisms #multiplesclerosiswarrior #healingmultiplesclerosis

First..
Save this reel so you can come back to it and send it to a bestie so they can feel better too!!

Now.. how do you feel after taking that breath?

A little more calm, centered and focused?
Probably.

How we breathe is such a huge piece of the nervous system regulation puzzle, this well def help in your efforts.

Give it a try a few times a day, and let me know what you notice!!

If we haven’t met yet, Hi! 👋🏼👋🏼 I’m Alissa.

I’m a Holistic Practitioner & Therapist specializing in MS.
I use all the tools I’ve comprised over my 10+ year career (and 15+ years with MS) to help my clients decrease their symptoms, improve their overall health and get back to living life on their terms, not MS’ terms.

I currently have 2 Individual Coaching spots open!! (if you live in MA I take some insurance!!)
Comment 🧡 below to learn more!!

#lissms #multiplesclerosis #nervoussystemregulation #becausems #thisisms #multiplesclerosiswarrior #healingmultiplesclerosis
...

9 0
5 Habits to Help MS Symptoms 

In no particular order:
• Food/ our diet
• Movement 
• Breathing 
• Tracking/Review
• Joy! Fun! Presence!

Want my free Eating for MS Guide? Comment FOOD and I’ll send it to you!

Want my 3 minute morning routine that helps your brain, body and mind?
Comment MOVE and I’ll send it to you!

Let me know if you like these lives and want to hear about more topics!

5 Habits to Help MS Symptoms

In no particular order:
• Food/ our diet
• Movement
• Breathing
• Tracking/Review
• Joy! Fun! Presence!

Want my free Eating for MS Guide? Comment FOOD and I’ll send it to you!

Want my 3 minute morning routine that helps your brain, body and mind?
Comment MOVE and I’ll send it to you!

Let me know if you like these lives and want to hear about more topics!
...

9 6
5 Underrated Supplements to help MS symptoms 

In no particular order:
• ALA- Alpha Lipoic Acid
• NAC N-Acetylcystine
• Lions Mane Mushroom
• NADH/NAD+
• Pre/Probiotics

Have you tried any of these before??
What has been your experience?

5 Underrated Supplements to help MS symptoms

In no particular order:
• ALA- Alpha Lipoic Acid
• NAC N-Acetylcystine
• Lions Mane Mushroom
• NADH/NAD+
• Pre/Probiotics

Have you tried any of these before??
What has been your experience?
...

10 0
5 things to keep in mind about nutrition and MS

1. Addition before subtraction 
2. Eat your fruits, veggies and fats
3. Think about how you’re eating vs what you’re eating
4. Hydrate!!
5. Consider elimination if needed

More questions on food for MS?
Grab your Eating for MS Guide in my bio!!

5 things to keep in mind about nutrition and MS

1. Addition before subtraction
2. Eat your fruits, veggies and fats
3. Think about how you’re eating vs what you’re eating
4. Hydrate!!
5. Consider elimination if needed

More questions on food for MS?
Grab your Eating for MS Guide in my bio!!
...

12 1
Just a guess…

Did I nail it? Almost? I bet.

I’ve seen the same patterns over and over within my clients (and tbh myself)

Growing up hyper independent..
Possibly not getting your needs met as a kid..
Feeling like you’re in control of it all girl boss style.. 
But unable to say no when asked to do anything.. 

You think you’re just being helpful, or kind, or smart..

In reality you’re keeping yourself stuck and sick.

Babe lemme tell you, there is a way out.

Embodied Resilience gives you that path out from under your unhelpful patterns (that always saying yes thing) and your over stressed life

Comment OUT below and I’ll send you details on the group.. we start next week!!

#lissms #multiplesclerosis #nervoussystemregulation #multiplesclerosiswarrior #nervoussystemhealing #thisisms #becausems #msawarenessmonth

Just a guess…

Did I nail it? Almost? I bet.

I’ve seen the same patterns over and over within my clients (and tbh myself)

Growing up hyper independent..
Possibly not getting your needs met as a kid..
Feeling like you’re in control of it all girl boss style..
But unable to say no when asked to do anything..

You think you’re just being helpful, or kind, or smart..

In reality you’re keeping yourself stuck and sick.

Babe lemme tell you, there is a way out.

Embodied Resilience gives you that path out from under your unhelpful patterns (that always saying yes thing) and your over stressed life

Comment OUT below and I’ll send you details on the group.. we start next week!!

#lissms #multiplesclerosis #nervoussystemregulation #multiplesclerosiswarrior #nervoussystemhealing #thisisms #becausems #msawarenessmonth
...

22 2
Stress & MS!!

• How our nervous system should function 
• Why it doesn’t work “right” in todays world
• How to support our nervous system & stress response

Stress & MS!!

• How our nervous system should function
• Why it doesn’t work “right” in todays world
• How to support our nervous system & stress response
...

13 0
First, comment SAFE below and I’ll send you details on my course Embodied Resilience- 
(Maybe the only live round this year) we start March 10th!!

Years and years ago, someone really confused me when they said meditating made their anxiety worse. 

My baby therapist-in-training brain thought, well crap- isn’t that supposed to help???

While yes, it is supposed to, it often doesn’t. 
(Especially if you’ve experienced trauma)

You see, before we get quiet with our thoughts in meditation, our bodies need to feel safe doing so. 

If you don’t feel safe in your body, meditation won’t “work”. 

I see this all the time in my clients:
• they’re going a mile a minute throughout the day..
• thinking 10 steps ahead of what they’re doing..
• ignoring their body all day..

then all of a sudden they sit down to try and meditate and- shocker- they “can’t”

You too? You’re not broken- promise 🧡🧡

Try this instead: 
- Stop what you’re doing and actually sit down (I’ll wait)
- Close your eyes, take a few deep breaths and focus on a loud whooooooshing exhale
- Put your hand on your chest and notice what your body is physically feeling (tight chest? Hole in your stomach? Exhaustion?)
- Gently sway/rock your shoulders back and forth
- Open your eyes and come back to your surroundings. Look around the room and name a few objects you see around you out loud. 
- How did that feel to your mind and body? 

If you’ve been trying all the things to help reduce stress + calm your body and mind but find they “don’t work” I invite you into Embodied Resilience. 

This is one of my signature programs designed to help you learn how to actually manage stress in an effective way, so stress doesn’t cause a MS symptom flare or worse- full blown relapse. 

We’re still in pre-sale, so to get the best price grab your spot now!! 

#lissms #thisisms #becausems #multiplesclerosis #nervoussystemregulation #nervoussystemhealing #healingmultiplesclerosis #multiplesclerosiswarrior

First, comment SAFE below and I’ll send you details on my course Embodied Resilience-
(Maybe the only live round this year) we start March 10th!!

Years and years ago, someone really confused me when they said meditating made their anxiety worse.

My baby therapist-in-training brain thought, well crap- isn’t that supposed to help???

While yes, it is supposed to, it often doesn’t.
(Especially if you’ve experienced trauma)

You see, before we get quiet with our thoughts in meditation, our bodies need to feel safe doing so.

If you don’t feel safe in your body, meditation won’t “work”.

I see this all the time in my clients:
• they’re going a mile a minute throughout the day..
• thinking 10 steps ahead of what they’re doing..
• ignoring their body all day..

then all of a sudden they sit down to try and meditate and- shocker- they “can’t”

You too? You’re not broken- promise 🧡🧡

Try this instead:
- Stop what you’re doing and actually sit down (I’ll wait)
- Close your eyes, take a few deep breaths and focus on a loud whooooooshing exhale
- Put your hand on your chest and notice what your body is physically feeling (tight chest? Hole in your stomach? Exhaustion?)
- Gently sway/rock your shoulders back and forth
- Open your eyes and come back to your surroundings. Look around the room and name a few objects you see around you out loud.
- How did that feel to your mind and body?

If you’ve been trying all the things to help reduce stress + calm your body and mind but find they “don’t work” I invite you into Embodied Resilience.

This is one of my signature programs designed to help you learn how to actually manage stress in an effective way, so stress doesn’t cause a MS symptom flare or worse- full blown relapse.

We’re still in pre-sale, so to get the best price grab your spot now!!

#lissms #thisisms #becausems #multiplesclerosis #nervoussystemregulation #nervoussystemhealing #healingmultiplesclerosis #multiplesclerosiswarrior
...

5 3
This is where I start all my clients when they want to start working on their:
- stress management and response
- nervous system regulation
- undoing the unhelpful behavior patterns that got us sick (people pleasing, perfectionism etc)

And the first step I’ll share in my masterclass tomorrow, Cultivating Resilience, all about stress + MS.
 I’ll tell you about the rest of the process too. 

Haven’t signed up yet? There’s still time!!
Comment STRESS below and I’ll send you the link to sign up!!

#lissms #multiplesclerosis #nervoussystemregulation #stressmanagement #healingmultiplesclerosis #thisisms #becausems

This is where I start all my clients when they want to start working on their:
- stress management and response
- nervous system regulation
- undoing the unhelpful behavior patterns that got us sick (people pleasing, perfectionism etc)

And the first step I’ll share in my masterclass tomorrow, Cultivating Resilience, all about stress + MS.
I’ll tell you about the rest of the process too.

Haven’t signed up yet? There’s still time!!
Comment STRESS below and I’ll send you the link to sign up!!

#lissms #multiplesclerosis #nervoussystemregulation #stressmanagement #healingmultiplesclerosis #thisisms #becausems
...

18 5
More ways my life has changed 
👇🏼👇🏼

- less nail biting
- my tiggers aren’t as loud and I can move through them without shutting down
- I dissociate less when experiencing really hard things 
- conflicts are shorter with the hubby
- I’m able to ask for what I need 
- more enjoyment day to day
- more dancing and fun
- more attending to my own needs 
- putting myself first
- boundaries!!

These don’t necessarily scream “they’ll help your MS symptoms too” 
But they absolutely will!!

I’m hosting a Masterclass all about stress + MS- and how we can help ourselves manage stress more effectively which in turn helps us to manage MS more effectively.

The class is happening Tuesday evening- comment STRESS below and I’ll send you the link to register so you don’t miss it!!

#lissms #multiplesclerosis #nervoussystemregulation #thisisms #becausems #nervoussystemhealing #healingmultiplesclerosis #multiplesclerosiswarrior #multiplesclerosisawareness

More ways my life has changed
👇🏼👇🏼

- less nail biting
- my tiggers aren’t as loud and I can move through them without shutting down
- I dissociate less when experiencing really hard things
- conflicts are shorter with the hubby
- I’m able to ask for what I need
- more enjoyment day to day
- more dancing and fun
- more attending to my own needs
- putting myself first
- boundaries!!

These don’t necessarily scream “they’ll help your MS symptoms too”
But they absolutely will!!

I’m hosting a Masterclass all about stress + MS- and how we can help ourselves manage stress more effectively which in turn helps us to manage MS more effectively.

The class is happening Tuesday evening- comment STRESS below and I’ll send you the link to register so you don’t miss it!!

#lissms #multiplesclerosis #nervoussystemregulation #thisisms #becausems #nervoussystemhealing #healingmultiplesclerosis #multiplesclerosiswarrior #multiplesclerosisawareness
...

19 3
Is people pleasing or perfectionism signs of stress?

You betcha.

Not only are they adding to your mental & physical load via ignoring your needs, demanding perfection from yourself, etc etc..

Having less flexibility in your emotions and actions tells me a lot about your nervous system and how dysregulated you are.

When we have less flexibility in our emotions or how we relate to ourselves, that usually means our nervous system lacks flexibility to manage our daily stressors effectively.

Meaning- you struggle to not feel like an anxious, out of control mess
Or like an exhausted pile of mush

The answer is cultivating resilience in your nervous system & body so that you are able to handle the stress without increasing MS symptoms or these unhelpful patterns.

Wanna know my blueprint I’ve used to help my clients finally come out of years of (partially self inflicted) stress? 

I’m hosting a free Masterclass next week allll about stress + MS, and how to live WITH stress, cause it ain’t goin anywhere.

Comment STRESS below and I’ll send you the link to register!!

#lissms #multiplesclerosis #nervoussystemregulation #nervoussystemhealing #becausems #thisisms #stressmanagement #multiplesclerosiswarrior #holisticliving

Is people pleasing or perfectionism signs of stress?

You betcha.

Not only are they adding to your mental & physical load via ignoring your needs, demanding perfection from yourself, etc etc..

Having less flexibility in your emotions and actions tells me a lot about your nervous system and how dysregulated you are.

When we have less flexibility in our emotions or how we relate to ourselves, that usually means our nervous system lacks flexibility to manage our daily stressors effectively.

Meaning- you struggle to not feel like an anxious, out of control mess
Or like an exhausted pile of mush

The answer is cultivating resilience in your nervous system & body so that you are able to handle the stress without increasing MS symptoms or these unhelpful patterns.

Wanna know my blueprint I’ve used to help my clients finally come out of years of (partially self inflicted) stress?

I’m hosting a free Masterclass next week allll about stress + MS, and how to live WITH stress, cause it ain’t goin anywhere.

Comment STRESS below and I’ll send you the link to register!!

#lissms #multiplesclerosis #nervoussystemregulation #nervoussystemhealing #becausems #thisisms #stressmanagement #multiplesclerosiswarrior #holisticliving
...

18 3

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