Treatment Options: Infusion Medications


Infusion Medications

The past few weeks we have been discussing the various types of treatments for multiple sclerosis including injectable medications and oral medications. This week we will be discussing infusion medications. There are only four medications in this category, two of which have been approved just recently, Tysabri, Novantrone, Lemtrada and Ocrevus. Let’s take a closer look at each of them.

Tysabri

Tysabri is a monoclonal antibody that is designed to prevent damaging immune cells from entering the bloodstream and crossing the blood brain barrier into the brain and spinal cord. It was approved by the FDA in 2004 for the use in MS. Tysabri is considered an immuno suppressant medication, and should not be used in combination with any other medications that affect the immune system. It is given via infusion once a month at a hospital, local infusion center or doctors office. Usually the infusion itself takes around an hour, then the individual must be observed for an hour afterwards to make sure there are no complications or reactions to the medication. Tysabri is usually considered when other medications have been tried and have not been successful.
There is a very serious, but rare, risk of taking tysabri (and other immno suppressant medications), PML. PML (Progressive multifocal leukoencephalopathy) is a potentially fatal brain infection that can be caused by the JC virus. If you are taking other medications that suppress your immune system, have been taking tysabri for a longer period of time (over two years), or test positive for the JC virus, your risk of getting PML increases. While taking tysabri, you will be monitored every six months via blood test for the JC virus. PML can be tricky to spot, as the symptoms are very similar to symptoms of MS. Clumsiness, vision changes, weakness on one side of the body, personality changes and problems with cognition (thinking, memory and orientation leading to confusion). If you ever experience some of the symptoms and think you may have PML, it is important that you call your doctor immediately.
Other side effects of tysabri can include headache, fatigue, chest/abdominal discomfort, diarrhea, depression, rash and joint pain. Tysabri can also cause liver damage which can be monitored and detected by blood tests. Just another reason to be keeping up with regular appointments and blood work.
Although there are many warnings and potential side effects, many patients have reviewed this medication and called it “liquid gold”. They find it has helped with their symptoms immensely.

Novantrone

Novantrone is an antineoplastic (anti-cancer) medication that is a DNA reactive agent, meaning it causes damage to DNA. It was approved by the FDA in 2000 for the use in MS. Novantrone works by stopping the proliferation of B cells and T cells and macrophages, which all play a role in the immune response that is thought to be involved in MS. It is indicated for people with secondary progressive MS, progressive relapsing MS or worsening relapsing remitting MS. Novantrone is given via infusion that takes 5-15 minutes. Due to potential damage to your heart, you shouldn’t take more than 140mg in your lifetime, this will limit your treatment to 2-3 years.
Before starting to take Novantrone, you’ll have a heart test that will look for a problem called “left ventricular ejection fraction (LVEF)”. If you have a clinically significant reduction or a 50% reduction in LVEF, you should not take Novantrone. Also, if your neutrophill count is below 1500 cells/mm you shouldn’t take it. Novantrone will clear more slowly from your body if your liver function is impaired, as well. Therefore you will need to be tested for proper liver function prior to starting Novantrone.
Common side effects from Novantrone can include nausea, temporary hair thinning, temporary blue-green urine, urinary tract and airway infections, uneven heart rate, weight gain and chest pain/tightness. More serious side effects can include heart disease, liver damage and therapy-related acute leukemia (TRAL).

Lemtrada

Lemtrada is a monoclonal antibody that focuses on CD52 (a protein on the surface of immune cells) and causes depletion of lymphocytes. It was approved by the FDA in 2014 for the use in MS. Originally, it was used and approved at a much higher dose for the treatment of chronic lymphocytic leukemia. It’s ability to target immune cells lead scientist to test its potential as a treatment for MS. Lemtrada is given by infusion for five consecutive days at first, then three consecutive days a year later.
There are serious side effects associated with Lemtrada. A rare bleeding condition, a rare kidney condition, life-threatening infusion reactions, increased risk of cancers and autoimmune thyroid disorders. Yikes!!
More common and less severe side effects include  rash, headache, fever, nasal congestion, nausea, urinary tract infection, fatigue, insomnia, upper respiratory tract infection, herpes viral infection, hives, itching, thyroid gland disorders, fungal infection, pain in joints, extremities and back, diarrhea, sinusitis, sore mouth and throat, tingling, dizziness, abdominal pain, flushing and vomiting.
Prior to starting the medication, an individual should be vaccinated for varicella, their thyroid function should be tested and then monitored every three months, they should receive a full CBC and urinalysis once a month until 48 months after last infusion and they should have a skin exam yearly to monitor for melanoma. 

Ocrevus

 
Ocrevus is the newest medication on the scene. It was approved by the FDA in early 2017 for the use in primary progressive MS, and is the first medication to be approved for primary progressive MS. Ocrevus is a monoclonal antibody that targets CD20 positive B lymphocytes. These lymphocytes contribute to nerve damage in MS. Ocrevus is given via infusion in a infusion center or doctors office. The initial dose is split up over two weeks. In the first infusion 300 mg is infused then two weeks later another 300 mg. Each of these infusions takes at least 2 1/2 hours. After the first two doses, you will get one infusion every six months which will take at least 3 1/2 hours. Prior to your first dose you will need to be screened for hepatitis B.
As with the other medications, there are many potential side effects. Fatigue, coughing, fever, shortness of breath, nausea, headache or all possible. Infusion related reactions may occur as well. These may include throat irritation, headache, flushing, mild fever or rash. During clinical trials several individuals developed abnormal growths of tissue, the links between these growths and the medication are still not known. 
It is clear that these medications are very strong. Many of them include the caveat of “try others first”. When deciding on one of these medications, it is a very individual decision. You can talk to as many people as you want, but in the end, how the medication will affect you comes down to your body and your biology. You’ll never truly know how something will work, or not work, until you try it.
 
I’ve been on tysabri for just over two years. Before starting the medication I read numerous patient reviews. It seemed like one person loved it then the next hated it and this continued for pages and pages. I finally realize that I just needed to try it for myself. When I first started it, after I would have an infusion I would be exhausted, like spend the rest of the day on the couch and do nothing exhausted. As the infusions went on, the exhaustion lessened. Eventually I got to the point where I am now. I can walk into the infusion center get my infusion and then go on with my day, *almost* like nothing happened. 

I’M ALISSA!

I help women who have also been diagnosed with Multiple Sclerosis make specific and personalized diet, lifestyle & subconscious changes so that they can begin to heal their body, reduce disease symptoms, and return to a life they love.hey there,

follow along on Instagram:

But seriously.. this isn’t too far off 😂

Life handed me a lemon that was a MS diagnosis at 24. 
Life handed me a lemon that was multiple relapses and MS progression by 30.

Then I snatched those lemons, made some healing lemonade, and feel night and day different than I did 10 years ago when my symptoms were at their worst. 

I could do it, my clients are doing it, I know you can too.

That’s why I’m so passionate about doing what I do. I know it’s possible for you to feel better in your body and be able to do the things you want to do. 

Like go for a walk or hike with your spouse, say yes to a spontaneous night out with friends or get up and down off the floor playing with your kids. 

That’s why I want to invite you to the waitlist for what I have coming.

Think, somewhere to go online, where you can: connect with others who have MS, get questions about MS answered, get tools that can help your symptoms, support & accountability to help with actually doing those things.

Comment WAITLIST below and ill send you the link to join the list 

#lissms #multiplesclerosis #multiplesclerosiswarrior #becausems #thisisms #communityheals #mscommunity

But seriously.. this isn’t too far off 😂

Life handed me a lemon that was a MS diagnosis at 24.
Life handed me a lemon that was multiple relapses and MS progression by 30.

Then I snatched those lemons, made some healing lemonade, and feel night and day different than I did 10 years ago when my symptoms were at their worst.

I could do it, my clients are doing it, I know you can too.

That’s why I’m so passionate about doing what I do. I know it’s possible for you to feel better in your body and be able to do the things you want to do.

Like go for a walk or hike with your spouse, say yes to a spontaneous night out with friends or get up and down off the floor playing with your kids.

That’s why I want to invite you to the waitlist for what I have coming.

Think, somewhere to go online, where you can: connect with others who have MS, get questions about MS answered, get tools that can help your symptoms, support & accountability to help with actually doing those things.

Comment WAITLIST below and ill send you the link to join the list

#lissms #multiplesclerosis #multiplesclerosiswarrior #becausems #thisisms #communityheals #mscommunity
...

11 2
I have a saying about dealing with MS (and any other autoimmune/chronic illnesses) that inevitably comes up in my work with clients:
“You don’t get it, until you get it”

Meaning, you don’t understand living life with MS (or any of the above), until you live in a body that has it.

Which is why living with MS can be so tough and lonely, because its hard to find people that truly understand what you mean when you say you’re exhausted, or brain foggy or “fine”.

This is also why I believe that having a community of others who get it is invaluable.

I’ve seen countless times over where someone new to one of my groups is able to feel fully seen and heard for the first time, and that is priceless for them and their healing.

They walk away feeling validated, understood and at home, which are hard to come by at the doctors office 😂🙄

You’re not too much
You’re not alone
You’re not lazy
You’re just talking to the wrong people.

If you wanna talk to the right people, I’m creating something for you..

Think, somewhere to go online, where you can: connect with others who have MS, get questions about MS answered, get tools that can help your symptoms, support & accountability to help with actually doing those things.. 

BUT- only the waitlist is going to hear about it. So- if you want to be notified and involved in creating whats coming, comment WAITLIST and you’re in 

#lissms #multiplesclerosis #multiplesclerosiscommunity #thisisms #becausems #multiplesclerosissupport

I have a saying about dealing with MS (and any other autoimmune/chronic illnesses) that inevitably comes up in my work with clients:
“You don’t get it, until you get it”

Meaning, you don’t understand living life with MS (or any of the above), until you live in a body that has it.

Which is why living with MS can be so tough and lonely, because its hard to find people that truly understand what you mean when you say you’re exhausted, or brain foggy or “fine”.

This is also why I believe that having a community of others who get it is invaluable.

I’ve seen countless times over where someone new to one of my groups is able to feel fully seen and heard for the first time, and that is priceless for them and their healing.

They walk away feeling validated, understood and at home, which are hard to come by at the doctors office 😂🙄

You’re not too much
You’re not alone
You’re not lazy
You’re just talking to the wrong people.

If you wanna talk to the right people, I’m creating something for you..

Think, somewhere to go online, where you can: connect with others who have MS, get questions about MS answered, get tools that can help your symptoms, support & accountability to help with actually doing those things..

BUT- only the waitlist is going to hear about it. So- if you want to be notified and involved in creating whats coming, comment WAITLIST and you’re in

#lissms #multiplesclerosis #multiplesclerosiscommunity #thisisms #becausems #multiplesclerosissupport
...

11 3
As I type this post, we’re on the way to 100 degrees today and we’re in the middle of a heat wave.
🥵 is an understatement lol.

If you’re an MSer.. you know an increase in temperature can cause our already compromised neurons to work even less effectively than normal.

There’s a few things I have found helpful for managing the heat: 

BE PROACTIVE: Instead of waiting until you’re about to melt, use cooling strategies before you really need them.

CREATE AN OASIS: If you don’t have central AC in your house, make (at least) one room in your house a cool oasis to hide in. 

ACCESSORIZE: Get alllll the cooling products. @koldtec @releafpack and a cooling vest are a must! 

HYDRATE: Drink plenty of water and add electrolytes! Trace Minerals is my fav, but there is Buoy, LMNT or Liquid IV too! 

But most of all, make sure to advocate for yourself and your comfort. 

You deserve comfort as well as any other person.
Please don’t let anxiety and fear of “ruining” a summer day keep you from asking/stating what you need.

What are your top ways to stay cool?? Tell us below! 

PS!!
I’m deep in the trenches creating a one stop shop for anything and everything MS healing. A place where you can plug into and get ideas for recipes, workouts, stress management and living life with MS.
As well as support and understanding from people who get what it means to live with an autoimmune disease.

Only the waitlist will get an invite- comment WAITLIST below and I’ll add you!!

#lissms #multiplesclerosis #thisisms #becausems #heatintolerance #healingmultiplesclerosis

As I type this post, we’re on the way to 100 degrees today and we’re in the middle of a heat wave.
🥵 is an understatement lol.

If you’re an MSer.. you know an increase in temperature can cause our already compromised neurons to work even less effectively than normal.

There’s a few things I have found helpful for managing the heat:

BE PROACTIVE: Instead of waiting until you’re about to melt, use cooling strategies before you really need them.

CREATE AN OASIS: If you don’t have central AC in your house, make (at least) one room in your house a cool oasis to hide in.

ACCESSORIZE: Get alllll the cooling products. @koldtec @releafpack and a cooling vest are a must!

HYDRATE: Drink plenty of water and add electrolytes! Trace Minerals is my fav, but there is Buoy, LMNT or Liquid IV too!

But most of all, make sure to advocate for yourself and your comfort.

You deserve comfort as well as any other person.
Please don’t let anxiety and fear of “ruining” a summer day keep you from asking/stating what you need.

What are your top ways to stay cool?? Tell us below!

PS!!
I’m deep in the trenches creating a one stop shop for anything and everything MS healing. A place where you can plug into and get ideas for recipes, workouts, stress management and living life with MS.
As well as support and understanding from people who get what it means to live with an autoimmune disease.

Only the waitlist will get an invite- comment WAITLIST below and I’ll add you!!

#lissms #multiplesclerosis #thisisms #becausems #heatintolerance #healingmultiplesclerosis
...

16 8
What she also didn’t know?
The MS diagnosis would be the best thing to happen to her

Ok maybe not best lol, but I now can see what a gift it was.

You see, the MS diagnosis I got eventually gave me a reckoning moment with my health.

Change something, or else this is gonna go downhill fast.
This being my body, my ability to move, to live doing the things I want to do.

And man did it help.

I went from “aggressive MS” to not even thinking about MS on some days.

This process I went through? That’s exactly what I help others with now.

I currently have 2 Individual Client spots open!! (1 might be gone soon though..)

We can work on..
✨How you’re feeling mentally & emotionally about your MS diagnosis.
✨Strategies to mitigate your symptoms, that include nutrition, movement and cognitive/emotional methods
✨Anything else your body needs 

Interested in what this would look like for you?
Comment 🧡🧡 below and I’ll send you details!!

#lissms #multiplesclerosis #nervoussystemregulation #thisisms #becausems #multiplesclerosiswarrior #multiplesclerosissupport

What she also didn’t know?
The MS diagnosis would be the best thing to happen to her

Ok maybe not best lol, but I now can see what a gift it was.

You see, the MS diagnosis I got eventually gave me a reckoning moment with my health.

Change something, or else this is gonna go downhill fast.
This being my body, my ability to move, to live doing the things I want to do.

And man did it help.

I went from “aggressive MS” to not even thinking about MS on some days.

This process I went through? That’s exactly what I help others with now.

I currently have 2 Individual Client spots open!! (1 might be gone soon though..)

We can work on..
✨How you’re feeling mentally & emotionally about your MS diagnosis.
✨Strategies to mitigate your symptoms, that include nutrition, movement and cognitive/emotional methods
✨Anything else your body needs

Interested in what this would look like for you?
Comment 🧡🧡 below and I’ll send you details!!

#lissms #multiplesclerosis #nervoussystemregulation #thisisms #becausems #multiplesclerosiswarrior #multiplesclerosissupport
...

25 2
First..
Save this reel so you can come back to it and send it to a bestie so they can feel better too!!

Now.. how do you feel after taking that breath?

A little more calm, centered and focused?
Probably.

How we breathe is such a huge piece of the nervous system regulation puzzle, this well def help in your efforts.

Give it a try a few times a day, and let me know what you notice!!

If we haven’t met yet, Hi! 👋🏼👋🏼 I’m Alissa.

I’m a Holistic Practitioner & Therapist specializing in MS. 
I use all the tools I’ve comprised over my 10+ year career (and 15+ years with MS) to help my clients decrease their symptoms, improve their overall health and get back to living life on their terms, not MS’ terms.

I currently have 2 Individual Coaching spots open!! (if you live in MA I take some insurance!!)
Comment 🧡 below to learn more!!

#lissms #multiplesclerosis #nervoussystemregulation #becausems #thisisms #multiplesclerosiswarrior #healingmultiplesclerosis

First..
Save this reel so you can come back to it and send it to a bestie so they can feel better too!!

Now.. how do you feel after taking that breath?

A little more calm, centered and focused?
Probably.

How we breathe is such a huge piece of the nervous system regulation puzzle, this well def help in your efforts.

Give it a try a few times a day, and let me know what you notice!!

If we haven’t met yet, Hi! 👋🏼👋🏼 I’m Alissa.

I’m a Holistic Practitioner & Therapist specializing in MS.
I use all the tools I’ve comprised over my 10+ year career (and 15+ years with MS) to help my clients decrease their symptoms, improve their overall health and get back to living life on their terms, not MS’ terms.

I currently have 2 Individual Coaching spots open!! (if you live in MA I take some insurance!!)
Comment 🧡 below to learn more!!

#lissms #multiplesclerosis #nervoussystemregulation #becausems #thisisms #multiplesclerosiswarrior #healingmultiplesclerosis
...

10 0
5 Habits to Help MS Symptoms 

In no particular order:
• Food/ our diet
• Movement 
• Breathing 
• Tracking/Review
• Joy! Fun! Presence!

Want my free Eating for MS Guide? Comment FOOD and I’ll send it to you!

Want my 3 minute morning routine that helps your brain, body and mind?
Comment MOVE and I’ll send it to you!

Let me know if you like these lives and want to hear about more topics!

5 Habits to Help MS Symptoms

In no particular order:
• Food/ our diet
• Movement
• Breathing
• Tracking/Review
• Joy! Fun! Presence!

Want my free Eating for MS Guide? Comment FOOD and I’ll send it to you!

Want my 3 minute morning routine that helps your brain, body and mind?
Comment MOVE and I’ll send it to you!

Let me know if you like these lives and want to hear about more topics!
...

11 6
5 Underrated Supplements to help MS symptoms 

In no particular order:
• ALA- Alpha Lipoic Acid
• NAC N-Acetylcystine
• Lions Mane Mushroom
• NADH/NAD+
• Pre/Probiotics

Have you tried any of these before??
What has been your experience?

5 Underrated Supplements to help MS symptoms

In no particular order:
• ALA- Alpha Lipoic Acid
• NAC N-Acetylcystine
• Lions Mane Mushroom
• NADH/NAD+
• Pre/Probiotics

Have you tried any of these before??
What has been your experience?
...

10 0
5 things to keep in mind about nutrition and MS

1. Addition before subtraction 
2. Eat your fruits, veggies and fats
3. Think about how you’re eating vs what you’re eating
4. Hydrate!!
5. Consider elimination if needed

More questions on food for MS?
Grab your Eating for MS Guide in my bio!!

5 things to keep in mind about nutrition and MS

1. Addition before subtraction
2. Eat your fruits, veggies and fats
3. Think about how you’re eating vs what you’re eating
4. Hydrate!!
5. Consider elimination if needed

More questions on food for MS?
Grab your Eating for MS Guide in my bio!!
...

12 1
Just a guess…

Did I nail it? Almost? I bet.

I’ve seen the same patterns over and over within my clients (and tbh myself)

Growing up hyper independent..
Possibly not getting your needs met as a kid..
Feeling like you’re in control of it all girl boss style.. 
But unable to say no when asked to do anything.. 

You think you’re just being helpful, or kind, or smart..

In reality you’re keeping yourself stuck and sick.

Babe lemme tell you, there is a way out.

Embodied Resilience gives you that path out from under your unhelpful patterns (that always saying yes thing) and your over stressed life

Comment OUT below and I’ll send you details on the group.. we start next week!!

#lissms #multiplesclerosis #nervoussystemregulation #multiplesclerosiswarrior #nervoussystemhealing #thisisms #becausems #msawarenessmonth

Just a guess…

Did I nail it? Almost? I bet.

I’ve seen the same patterns over and over within my clients (and tbh myself)

Growing up hyper independent..
Possibly not getting your needs met as a kid..
Feeling like you’re in control of it all girl boss style..
But unable to say no when asked to do anything..

You think you’re just being helpful, or kind, or smart..

In reality you’re keeping yourself stuck and sick.

Babe lemme tell you, there is a way out.

Embodied Resilience gives you that path out from under your unhelpful patterns (that always saying yes thing) and your over stressed life

Comment OUT below and I’ll send you details on the group.. we start next week!!

#lissms #multiplesclerosis #nervoussystemregulation #multiplesclerosiswarrior #nervoussystemhealing #thisisms #becausems #msawarenessmonth
...

22 2
Stress & MS!!

• How our nervous system should function 
• Why it doesn’t work “right” in todays world
• How to support our nervous system & stress response

Stress & MS!!

• How our nervous system should function
• Why it doesn’t work “right” in todays world
• How to support our nervous system & stress response
...

13 0
First, comment SAFE below and I’ll send you details on my course Embodied Resilience- 
(Maybe the only live round this year) we start March 10th!!

Years and years ago, someone really confused me when they said meditating made their anxiety worse. 

My baby therapist-in-training brain thought, well crap- isn’t that supposed to help???

While yes, it is supposed to, it often doesn’t. 
(Especially if you’ve experienced trauma)

You see, before we get quiet with our thoughts in meditation, our bodies need to feel safe doing so. 

If you don’t feel safe in your body, meditation won’t “work”. 

I see this all the time in my clients:
• they’re going a mile a minute throughout the day..
• thinking 10 steps ahead of what they’re doing..
• ignoring their body all day..

then all of a sudden they sit down to try and meditate and- shocker- they “can’t”

You too? You’re not broken- promise 🧡🧡

Try this instead: 
- Stop what you’re doing and actually sit down (I’ll wait)
- Close your eyes, take a few deep breaths and focus on a loud whooooooshing exhale
- Put your hand on your chest and notice what your body is physically feeling (tight chest? Hole in your stomach? Exhaustion?)
- Gently sway/rock your shoulders back and forth
- Open your eyes and come back to your surroundings. Look around the room and name a few objects you see around you out loud. 
- How did that feel to your mind and body? 

If you’ve been trying all the things to help reduce stress + calm your body and mind but find they “don’t work” I invite you into Embodied Resilience. 

This is one of my signature programs designed to help you learn how to actually manage stress in an effective way, so stress doesn’t cause a MS symptom flare or worse- full blown relapse. 

We’re still in pre-sale, so to get the best price grab your spot now!! 

#lissms #thisisms #becausems #multiplesclerosis #nervoussystemregulation #nervoussystemhealing #healingmultiplesclerosis #multiplesclerosiswarrior

First, comment SAFE below and I’ll send you details on my course Embodied Resilience-
(Maybe the only live round this year) we start March 10th!!

Years and years ago, someone really confused me when they said meditating made their anxiety worse.

My baby therapist-in-training brain thought, well crap- isn’t that supposed to help???

While yes, it is supposed to, it often doesn’t.
(Especially if you’ve experienced trauma)

You see, before we get quiet with our thoughts in meditation, our bodies need to feel safe doing so.

If you don’t feel safe in your body, meditation won’t “work”.

I see this all the time in my clients:
• they’re going a mile a minute throughout the day..
• thinking 10 steps ahead of what they’re doing..
• ignoring their body all day..

then all of a sudden they sit down to try and meditate and- shocker- they “can’t”

You too? You’re not broken- promise 🧡🧡

Try this instead:
- Stop what you’re doing and actually sit down (I’ll wait)
- Close your eyes, take a few deep breaths and focus on a loud whooooooshing exhale
- Put your hand on your chest and notice what your body is physically feeling (tight chest? Hole in your stomach? Exhaustion?)
- Gently sway/rock your shoulders back and forth
- Open your eyes and come back to your surroundings. Look around the room and name a few objects you see around you out loud.
- How did that feel to your mind and body?

If you’ve been trying all the things to help reduce stress + calm your body and mind but find they “don’t work” I invite you into Embodied Resilience.

This is one of my signature programs designed to help you learn how to actually manage stress in an effective way, so stress doesn’t cause a MS symptom flare or worse- full blown relapse.

We’re still in pre-sale, so to get the best price grab your spot now!!

#lissms #thisisms #becausems #multiplesclerosis #nervoussystemregulation #nervoussystemhealing #healingmultiplesclerosis #multiplesclerosiswarrior
...

4 2

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