Treatment Options: Medications in the Pipeline


New Medications in the Pipeline

For the past three weeks we have looked at the different categories of medications available for multiple sclerosis, injectable medications, oral medications and infused medications. This week we will take a look at the medications that are up-and-coming in the research pipeline. There are numerous studies going on currently, far too many to list all of them in one post, but we will look at some of the biggest studies going on right now.

Laquinimod

Laquinimod is a oral medication that is currently in phase 2 and phase 3 clinical trials. In 2014 it was refused a license for relapsing remitting MS due to poor trial results. It is now being studied for both relapsing remitting and primary progressive MS.
Laquinimod is thought to alter behavior of a me in cells and preventing them from crossing the blood brain barrier and damaging myelin. It also looks like Laquinimod can reduce inflammation and protect nerve structures and functions.
Several studies over the past few years were not promising. The drug did not reduce the relapse rate as compared to a placebo, but it did reduce rates of brain shrinkage and disability progression.

Ofatumumab

Ofatumumab is an injection or an infusion that is being researched for relapsing MS. Phase 2 trials were completed and now Phase 3 trials have begun. In these phase 3 trials the medication is injected under the skin every four weeks. Ofatumumab is an antibody and is thought to work by binding to the surface of a specific immune cell, B cells, and reduce their numbers.
In past clinical trials the results were very promising. Ofatumumab reduced relapse rates and slowed worsening of disability more effectively than Aubagio and Ofatumumab reduced new brain lesions by up to 90% as compared with placebos.

HSCT

HSCT is an intense chemotherapy treatment for multiple sclerosis, it is also known as stem cell treatment. It works by removing harmful immune cells then the individuals own stem cells are used to regrow the immune system.
There are several clinical trials that are going on using stem cell treatment for MS. Usually the individuals involved in these trials have had disease progression despite being on medication previously.
Results have been generally promising and showed that stem cell therapy has been effective at reducing relapses. Several studies also showed that stem cell therapy has been able to reduce disease progression as evidenced by improved EDSS scores.
There are over a hundred clinical trials currently going on looking for new treatments for Multiple Sclerosis and it’s related symptoms. Various studies include “Pilot study of Mirabegron and behavioral modification including pelvic floor exercise for overactive bladder in multiple sclerosis (MIRROR)” which is in Phase 4 and “A Multiple Dose Study of ABT-555 in Subjects With Relapsing Forms of Multiple Sclerosis” which is in Phase 1.
It is an exciting time in MS research. Hopefully more treatments that look at gut flora and the effects it has on MS progression will be completed soon as well!

I’M ALISSA!

I help women who have also been diagnosed with Multiple Sclerosis make specific and personalized diet, lifestyle & subconscious changes so that they can begin to heal their body, reduce disease symptoms, and return to a life they love.hey there,

follow along on Instagram:

It’s amazing what taking a few minutes to breathe and reassure yourself can do, ya know??

If you have MS and this gives you an immediate uncomfy feeling in your gut because you never advocate for yourself and your needs, 

You need to come to my next Masterclass:
Managing Stress to Manage MS

We’ll be talking about:
* How Stress Works: Discover how your body’s stress response system operates and why it plays such a big role in your overall health.
* Stress and MS: Understand how stress impacts MS symptoms and why it can sometimes make symptom flares worse.
* Building Your Resilience: Get simple, effective strategies to boost your stress resilience and help ease MS symptoms for a healthier, more balanced life.

Happening February 10th at 6pm EST!
Comment NEEDS below and I’ll send you the link to register! 

#multiplesclerosis #lissms #nervoussystemregulation #nervoussystemhealing #healingmultiplesclerosis #thisisms

It’s amazing what taking a few minutes to breathe and reassure yourself can do, ya know??

If you have MS and this gives you an immediate uncomfy feeling in your gut because you never advocate for yourself and your needs,

You need to come to my next Masterclass:
Managing Stress to Manage MS

We’ll be talking about:
* How Stress Works: Discover how your body’s stress response system operates and why it plays such a big role in your overall health.
* Stress and MS: Understand how stress impacts MS symptoms and why it can sometimes make symptom flares worse.
* Building Your Resilience: Get simple, effective strategies to boost your stress resilience and help ease MS symptoms for a healthier, more balanced life.

Happening February 10th at 6pm EST!
Comment NEEDS below and I’ll send you the link to register!

#multiplesclerosis #lissms #nervoussystemregulation #nervoussystemhealing #healingmultiplesclerosis #thisisms
...

4 1
This is hard!!

We feel like “we should be able to” still do the cleaning, chores, putting things away etc etc etc.. 

But in reality- our bodies need and crave rest and recovery first.

If we don’t give our bodies what they need voluntarily, they’ll find a way to make us.

Really struggle with this idea of listening to and caring for your body?
(I get it- it’s not a skill we’re taught)

I’m hosting a (free) masterclass on this and “managing stress” in January, comment CLASS and I’ll send you the link to sign up!! 

#multiplesclerosis #nervoussystemregulation #nervoussystemhealing #stressmanagement #lissms #thisisms #becausems #seasonaldepression #anxiety

This is hard!!

We feel like “we should be able to” still do the cleaning, chores, putting things away etc etc etc..

But in reality- our bodies need and crave rest and recovery first.

If we don’t give our bodies what they need voluntarily, they’ll find a way to make us.

Really struggle with this idea of listening to and caring for your body?
(I get it- it’s not a skill we’re taught)

I’m hosting a (free) masterclass on this and “managing stress” in January, comment CLASS and I’ll send you the link to sign up!!

#multiplesclerosis #nervoussystemregulation #nervoussystemhealing #stressmanagement #lissms #thisisms #becausems #seasonaldepression #anxiety
...

14 5
I get it..

It seems like it would be good.

Because others around you are taken care of..
Because others around you feel good..
Because others around you are happy..

But what about you??

In reality, that’s just making it harder for you to help yourself heal and probs making your MS symptoms worse.

I’ve worked with so many people with MS and autoimmune disease… 1 thing (among many) that they all have in common is a habit of putting others before themselves, saying yes way too much and forgetting about what they want themselves.

Feel a little called out?
Then my course Embodied Resilience is for you.

This is a course all about managing + improving your stress tolerance- since stress is the number 1 trigger of symptom flares and relapses

And- it’s on sale for Black Friday!!
Comment SALE below and I’ll send you the link!!

#lissms #multiplesclerosis #healingmultiplesclerosis #thisisms #becausems

I get it..

It seems like it would be good.

Because others around you are taken care of..
Because others around you feel good..
Because others around you are happy..

But what about you??

In reality, that’s just making it harder for you to help yourself heal and probs making your MS symptoms worse.

I’ve worked with so many people with MS and autoimmune disease… 1 thing (among many) that they all have in common is a habit of putting others before themselves, saying yes way too much and forgetting about what they want themselves.

Feel a little called out?
Then my course Embodied Resilience is for you.

This is a course all about managing + improving your stress tolerance- since stress is the number 1 trigger of symptom flares and relapses

And- it’s on sale for Black Friday!!
Comment SALE below and I’ll send you the link!!

#lissms #multiplesclerosis #healingmultiplesclerosis #thisisms #becausems
...

24 7
✨Moving your body✨

Notice I didn’t say exercise, although yes that also helps.

Stress hormones can get stuck in our bodies, our cells, our muscle tissue for various reasons.

Making it super easy for us to carry stress around with us- which shows up often as:

Pain
Tension
Trouble breathing
Difficulty with balance

It’s no coincidence that these are often prominent MS symptoms too. Sometimes it’s hard to tell where effects of MS end and effects of stress begin.

Being able to offload accumulated stress is key to being able to improve MS symptoms.

My course Embodied Resilience shows you exactly how to do this, and it’s gonna be on sale for Black Friday.

Comment ME below and I’ll send you the sale link when it’s ready!! 

#lissms #multiplesclerosis #nervoussystemhealing #nervoussystemregulation #stressmanagement #thisisms #becausems

✨Moving your body✨

Notice I didn’t say exercise, although yes that also helps.

Stress hormones can get stuck in our bodies, our cells, our muscle tissue for various reasons.

Making it super easy for us to carry stress around with us- which shows up often as:

Pain
Tension
Trouble breathing
Difficulty with balance

It’s no coincidence that these are often prominent MS symptoms too. Sometimes it’s hard to tell where effects of MS end and effects of stress begin.

Being able to offload accumulated stress is key to being able to improve MS symptoms.

My course Embodied Resilience shows you exactly how to do this, and it’s gonna be on sale for Black Friday.

Comment ME below and I’ll send you the sale link when it’s ready!!

#lissms #multiplesclerosis #nervoussystemhealing #nervoussystemregulation #stressmanagement #thisisms #becausems
...

9 2
I’ve seen myself and tons of clients through behavior change to help improve their MS + autoimmune disease symptoms.

There are SO MANY things that can help us.

But the one I’ve seen move the needle the most?

Working on your mindset and stress management tools.

We can change our diet
Change how we move 
Change the products we’re using
Change the supplements we take..

But if we’re still in the high stress state that most of us are in.. all those will only go so far.

Stress is my biggest symptom trigger, and 99% of my clients feel the same.

My biggest course sale is coming Black Friday, included is my course Embodied Resilience, all about learning how to actually manage stress- so you’re not constantly battling MS flares too.

My email list is gonna get first dibs..
Comment LIST below and I’ll add you so you’re notified first!!

I’ve seen myself and tons of clients through behavior change to help improve their MS + autoimmune disease symptoms.

There are SO MANY things that can help us.

But the one I’ve seen move the needle the most?

Working on your mindset and stress management tools.

We can change our diet
Change how we move
Change the products we’re using
Change the supplements we take..

But if we’re still in the high stress state that most of us are in.. all those will only go so far.

Stress is my biggest symptom trigger, and 99% of my clients feel the same.

My biggest course sale is coming Black Friday, included is my course Embodied Resilience, all about learning how to actually manage stress- so you’re not constantly battling MS flares too.

My email list is gonna get first dibs..
Comment LIST below and I’ll add you so you’re notified first!!
...

18 8
And my period started to add to the joy 🙃🙃

We can do hard things y’all,
breathe in, breathe out,
all will be well.

#Electionstress #seasonaldepression #anxiety #multiplesclerosis

And my period started to add to the joy 🙃🙃

We can do hard things y’all,
breathe in, breathe out,
all will be well.

#Electionstress #seasonaldepression #anxiety #multiplesclerosis
...

19 4
Home stretch!!

Do what you need to do today to take care of yourself friends.

#Electionday #Govote #Vote

Home stretch!!

Do what you need to do today to take care of yourself friends.

#Electionday #Govote #Vote
...

10 1
I think 90% of my clients have talked about already feeling the shift to Fall and Winter hardddd.

They are worried about seasonal depression coming back with a vengeance, feeling sad summer is gone and so many other things.

I know when so many feel the same way, you might too.
I know I feel this way too.

I’m working with them to put habits in place NOW that will support them through the winter months.

Here are 2 small shifts we talked about this week:

1. Get sunlight into your eyeballs as soon as you can in the morning.☀️☀️

Ideally this is outside, there will be many science bro’s out there telling you that anything else “doesn’t count” but I say that’s BS.
Yes, the sunlight will have a greater impact if you’re viewing outside, but even if you’re behind a window it will do something.

2. Move your body!! 💃🏃‍♀️

The change in seasons to colder weather makes it super easy to hibernate and move wayyy less than we were in the summer.
I know I’ve been guilty of that this week and it’s showing in my sleep.
But moving our bodies can be so helpful for regulating so many things in our bodies.
Ideally you’re moving in the morning, but again- any time of day will do. 

These are 2 small shifts that can make it easier for your body to transition to, and live with the Winter months.

Let’s crowdsource… what else helps you in winter?? 
I know there are many other things that can!!

I think 90% of my clients have talked about already feeling the shift to Fall and Winter hardddd.

They are worried about seasonal depression coming back with a vengeance, feeling sad summer is gone and so many other things.

I know when so many feel the same way, you might too.
I know I feel this way too.

I’m working with them to put habits in place NOW that will support them through the winter months.

Here are 2 small shifts we talked about this week:

1. Get sunlight into your eyeballs as soon as you can in the morning.☀️☀️

Ideally this is outside, there will be many science bro’s out there telling you that anything else “doesn’t count” but I say that’s BS.
Yes, the sunlight will have a greater impact if you’re viewing outside, but even if you’re behind a window it will do something.

2. Move your body!! 💃🏃‍♀️

The change in seasons to colder weather makes it super easy to hibernate and move wayyy less than we were in the summer.
I know I’ve been guilty of that this week and it’s showing in my sleep.
But moving our bodies can be so helpful for regulating so many things in our bodies.
Ideally you’re moving in the morning, but again- any time of day will do.

These are 2 small shifts that can make it easier for your body to transition to, and live with the Winter months.

Let’s crowdsource… what else helps you in winter??
I know there are many other things that can!!
...

11 4

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