Treatment Options: Medications in the Pipeline

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New Medications in the Pipeline

For the past three weeks we have looked at the different categories of medications available for multiple sclerosis, injectable medications, oral medications and infused medications. This week we will take a look at the medications that are up-and-coming in the research pipeline. There are numerous studies going on currently, far too many to list all of them in one post, but we will look at some of the biggest studies going on right now.

Laquinimod

Laquinimod is a oral medication that is currently in phase 2 and phase 3 clinical trials. In 2014 it was refused a license for relapsing remitting MS due to poor trial results. It is now being studied for both relapsing remitting and primary progressive MS.
Laquinimod is thought to alter behavior of a me in cells and preventing them from crossing the blood brain barrier and damaging myelin. It also looks like Laquinimod can reduce inflammation and protect nerve structures and functions.
Several studies over the past few years were not promising. The drug did not reduce the relapse rate as compared to a placebo, but it did reduce rates of brain shrinkage and disability progression.

Ofatumumab

Ofatumumab is an injection or an infusion that is being researched for relapsing MS. Phase 2 trials were completed and now Phase 3 trials have begun. In these phase 3 trials the medication is injected under the skin every four weeks. Ofatumumab is an antibody and is thought to work by binding to the surface of a specific immune cell, B cells, and reduce their numbers.
In past clinical trials the results were very promising. Ofatumumab reduced relapse rates and slowed worsening of disability more effectively than Aubagio and Ofatumumab reduced new brain lesions by up to 90% as compared with placebos.

HSCT

HSCT is an intense chemotherapy treatment for multiple sclerosis, it is also known as stem cell treatment. It works by removing harmful immune cells then the individuals own stem cells are used to regrow the immune system.
There are several clinical trials that are going on using stem cell treatment for MS. Usually the individuals involved in these trials have had disease progression despite being on medication previously.
Results have been generally promising and showed that stem cell therapy has been effective at reducing relapses. Several studies also showed that stem cell therapy has been able to reduce disease progression as evidenced by improved EDSS scores.
There are over a hundred clinical trials currently going on looking for new treatments for Multiple Sclerosis and it’s related symptoms. Various studies include “Pilot study of Mirabegron and behavioral modification including pelvic floor exercise for overactive bladder in multiple sclerosis (MIRROR)” which is in Phase 4 and “A Multiple Dose Study of ABT-555 in Subjects With Relapsing Forms of Multiple Sclerosis” which is in Phase 1.
It is an exciting time in MS research. Hopefully more treatments that look at gut flora and the effects it has on MS progression will be completed soon as well!

I’M ALISSA!

I help women who have also been diagnosed with Multiple Sclerosis make specific and personalized diet, lifestyle & subconscious changes so that they can begin to heal their body, reduce disease symptoms, and return to a life they love.hey there,

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This is how I slowly helped myself the most:
Making small changes to my life,
* Intentional awareness to my morning
* Noticing when I’m being mean to myself
* Noticing when I’m reactive or in a state of fight or flight..

Some “small” ideas for you too:
* don’t grab your phone first thing in the morning, take some deep breaths, think about how you want your day to go
* drink an extra glass of water (bonus if it’s in the morning too)
* get up and move every hour
* say something nice to yourself when you catch yourself being mean
* step outside for a few minutes a few times a day

Small changes add up to big steps forward,
don’t get fooled by these not being “enough”,
they absolutely are.

Wanna hear more about how Ive helped myself and my clients to lessen our MS symptoms so we feel better in our bodies?

I detail it in my chapter in Resilience Redefined.. comment “Book” and I’ll send you the link!!

20 5
Open
This is how I slowly helped myself the most: Making small changes to my life, * Intentional awareness to my morning * Noticing when I’m being mean to myself * Noticing when I’m reactive or in a state of fight or flight.. Some “small” ideas for you too: * don’t grab your phone first thing in the morning, take some deep breaths, think about how you want your day to go * drink an extra glass of water (bonus if it’s in the morning too) * get up and move every hour * say something nice to yourself when you catch yourself being mean * step outside for a few minutes a few times a day Small changes add up to big steps forward, don’t get fooled by these not being “enough”, they absolutely are. Wanna hear more about how Ive helped myself and my clients to lessen our MS symptoms so we feel better in our bodies? I detail it in my chapter in Resilience Redefined.. comment “Book” and I’ll send you the link!!

This is how I slowly helped myself the most:
Making small changes to my life,
* Intentional awareness to my morning
* Noticing when I’m being mean to myself
* Noticing when I’m reactive or in a state of fight or flight..

Some “small” ideas for you too:
* don’t grab your phone first thing in the morning, take some deep breaths, think about how you want your day to go
* drink an extra glass of water (bonus if it’s in the morning too)
* get up and move every hour
* say something nice to yourself when you catch yourself being mean
* step outside for a few minutes a few times a day

Small changes add up to big steps forward,
don’t get fooled by these not being “enough”,
they absolutely are.

Wanna hear more about how Ive helped myself and my clients to lessen our MS symptoms so we feel better in our bodies?

I detail it in my chapter in Resilience Redefined.. comment “Book” and I’ll send you the link!! ...

20 5

You don’t always have to love the hard action you’re taking to reach your goals.

You just have to show up.

You can do this… keep going 🧡🧡

*after discerning there’s no *actual* issue (pain, injury, illness etc) preventing me from working out, only that I’m a toddler and don’t wanna.

26 4
Open
You don’t always have to love the hard action you’re taking to reach your goals. You just have to show up. You can do this… keep going 🧡🧡 *after discerning there’s no *actual* issue (pain, injury, illness etc) preventing me from working out, only that I’m a toddler and don’t wanna.

You don’t always have to love the hard action you’re taking to reach your goals.

You just have to show up.

You can do this… keep going 🧡🧡

*after discerning there’s no *actual* issue (pain, injury, illness etc) preventing me from working out, only that I’m a toddler and don’t wanna. ...

26 4

“Resilience is the process and outcome of successfully adapting to difficult or challenging life experiences, especially through mental, emotional, and behavioral flexibility and adjustment to external and internal demands.”

Resilience has become such a cornerstone word of the work I do this past year.
It makes sense this book I collaborated on with 6 other awesome & resilient authors was destined to have resilience in the title.

Did you see??

Pre Orders are open!

If you pre order your copy through me before October 24th you’ll also get:
• Signed copy of Resilience Redefined
• The MS Handbook E-book
• Resilience Bookmark
• LissMS Sticker Pack (first 10 pre orders)

Grab your copy here:

https://liss-ms.com/product/resilience-redefined-thriving-with-autoimmune-disease/

Or comment Book below and I’ll send you the link!!

13 0
Open
“Resilience is the process and outcome of successfully adapting to difficult or challenging life experiences, especially through mental, emotional, and behavioral flexibility and adjustment to external and internal demands.” Resilience has become such a cornerstone word of the work I do this past year. It makes sense this book I collaborated on with 6 other awesome & resilient authors was destined to have resilience in the title. Did you see?? Pre Orders are open! If you pre order your copy through me before October 24th you’ll also get: • Signed copy of Resilience Redefined • The MS Handbook E-book • Resilience Bookmark • LissMS Sticker Pack (first 10 pre orders) Grab your copy here: https://liss-ms.com/product/resilience-redefined-thriving-with-autoimmune-disease/ Or comment Book below and I’ll send you the link!!

“Resilience is the process and outcome of successfully adapting to difficult or challenging life experiences, especially through mental, emotional, and behavioral flexibility and adjustment to external and internal demands.”

Resilience has become such a cornerstone word of the work I do this past year.
It makes sense this book I collaborated on with 6 other awesome & resilient authors was destined to have resilience in the title.

Did you see??

Pre Orders are open!

If you pre order your copy through me before October 24th you’ll also get:
• Signed copy of Resilience Redefined
• The MS Handbook E-book
• Resilience Bookmark
• LissMS Sticker Pack (first 10 pre orders)

Grab your copy here:

https://liss-ms.com/product/resilience-redefined-thriving-with-autoimmune-disease/

Or comment Book below and I’ll send you the link!! ...

13 0

Struggling to start with exercise?

Try this tip!!

Creating a new habit (any of them) necessitate us to become someone new, someone different than we were.

Because we’re trying to do something different after all.

This is gentle way of starting that identity shift process.

Become who you want to be in your mind first.

Does this help?
What other habits do you need help with? Let me know in the comments!!

31 3
Open
Struggling to start with exercise? Try this tip!! Creating a new habit (any of them) necessitate us to become someone new, someone different than we were. Because we’re trying to do something different after all. This is gentle way of starting that identity shift process. Become who you want to be in your mind first. Does this help? What other habits do you need help with? Let me know in the comments!!

Struggling to start with exercise?

Try this tip!!

Creating a new habit (any of them) necessitate us to become someone new, someone different than we were.

Because we’re trying to do something different after all.

This is gentle way of starting that identity shift process.

Become who you want to be in your mind first.

Does this help?
What other habits do you need help with? Let me know in the comments!! ...

31 3

It’s only fitting that I announce my 2nd book (along with 7 other authors) on my 14 year anniversary with MS.

This is a book that I would have loved to read early on in my journey.
It’s about how we moved through our diagnosis and came out the other side for the better.

““Resilience Redefined” is not just a collection of stories; it is a call to action. The authors challenge those living with an autoimmune disease to not only survive but to thrive”

So… drumroll please…
Pre orders are officially open!!

If you pre order your copy through me before October 24th you’ll also get:
• Signed copy of Resilience Redefined
• The MS Handbook E-book
• Resilience Bookmark
• LissMS Sticker Pack (first 10 pre orders)

Grab your copy here: https://liss-ms.com/product/resilience-redefined-thriving-with-autoimmune-disease/

Or comment “book” below and I’ll send you the link!!

33 15
Open
It’s only fitting that I announce my 2nd book (along with 7 other authors) on my 14 year anniversary with MS. This is a book that I would have loved to read early on in my journey. It’s about how we moved through our diagnosis and came out the other side for the better. ““Resilience Redefined” is not just a collection of stories; it is a call to action. The authors challenge those living with an autoimmune disease to not only survive but to thrive” So… drumroll please… Pre orders are officially open!! If you pre order your copy through me before October 24th you’ll also get: • Signed copy of Resilience Redefined • The MS Handbook E-book • Resilience Bookmark • LissMS Sticker Pack (first 10 pre orders) Grab your copy here: https://liss-ms.com/product/resilience-redefined-thriving-with-autoimmune-disease/ Or comment “book” below and I’ll send you the link!!

It’s only fitting that I announce my 2nd book (along with 7 other authors) on my 14 year anniversary with MS.

This is a book that I would have loved to read early on in my journey.
It’s about how we moved through our diagnosis and came out the other side for the better.

““Resilience Redefined” is not just a collection of stories; it is a call to action. The authors challenge those living with an autoimmune disease to not only survive but to thrive”

So… drumroll please…
Pre orders are officially open!!

If you pre order your copy through me before October 24th you’ll also get:
• Signed copy of Resilience Redefined
• The MS Handbook E-book
• Resilience Bookmark
• LissMS Sticker Pack (first 10 pre orders)

Grab your copy here: https://liss-ms.com/product/resilience-redefined-thriving-with-autoimmune-disease/

Or comment “book” below and I’ll send you the link!! ...

33 15

If you like being outside, check out the America the Beautiful Access Pass!

This is a pass for those with disabilities to get into National Parks, Monuments and more for FREE!!

You can get it online or at the entrance of a national park!

Share with anyone who also might like this!!

32 2
Open
If you like being outside, check out the America the Beautiful Access Pass! This is a pass for those with disabilities to get into National Parks, Monuments and more for FREE!! You can get it online or at the entrance of a national park! Share with anyone who also might like this!!

If you like being outside, check out the America the Beautiful Access Pass!

This is a pass for those with disabilities to get into National Parks, Monuments and more for FREE!!

You can get it online or at the entrance of a national park!

Share with anyone who also might like this!! ...

32 2

This is obvs one option of many on how to help yourself through these moments.

But when you’re stuck in negative worrying, don’t forget there can be a positive outcome too!

This is rewiring your brain in action.

You notice you’re doing something you always did,
Then do something different.

And boom! A new pathway is born.

It needs some love and attention to grow,
so keep practicing!

22 0
Open
This is obvs one option of many on how to help yourself through these moments. But when you’re stuck in negative worrying, don’t forget there can be a positive outcome too! This is rewiring your brain in action. You notice you’re doing something you always did, Then do something different. And boom! A new pathway is born. It needs some love and attention to grow, so keep practicing!

This is obvs one option of many on how to help yourself through these moments.

But when you’re stuck in negative worrying, don’t forget there can be a positive outcome too!

This is rewiring your brain in action.

You notice you’re doing something you always did,
Then do something different.

And boom! A new pathway is born.

It needs some love and attention to grow,
so keep practicing! ...

22 0

This isn’t a you problem, it’s your brain acting as it should.

Are you going through some change and upheaval right now too?

I see you.

Comment any questions on how to deal below and I’ll make a part 2!

38 2
Open
This isn’t a you problem, it’s your brain acting as it should. Are you going through some change and upheaval right now too? I see you. Comment any questions on how to deal below and I’ll make a part 2!

This isn’t a you problem, it’s your brain acting as it should.

Are you going through some change and upheaval right now too?

I see you.

Comment any questions on how to deal below and I’ll make a part 2! ...

38 2

We have a new space for my (free) LissMS Healing Community!!

Come on in…

Let me show you around!

This is a space created by an MSer (me), for other MSers (you) to be able to come together and support each other, learn new tools to help manage MS and maybe find a few new internet friends!

Wanna join us?

Comment “community” below and I’ll send you the link!!

16 1
Open
We have a new space for my (free) LissMS Healing Community!! Come on in… Let me show you around! This is a space created by an MSer (me), for other MSers (you) to be able to come together and support each other, learn new tools to help manage MS and maybe find a few new internet friends! Wanna join us? Comment “community” below and I’ll send you the link!!

We have a new space for my (free) LissMS Healing Community!!

Come on in…

Let me show you around!

This is a space created by an MSer (me), for other MSers (you) to be able to come together and support each other, learn new tools to help manage MS and maybe find a few new internet friends!

Wanna join us?

Comment “community” below and I’ll send you the link!! ...

16 1

There’s so much buzz about everything needing to feel good if it’s right for you.

Sure, there’s a time and a place for alignment.

But, growth often happens in the uncomfortable moments.

Just a reminder.
Keep going.
❤️

32 9
Open
There’s so much buzz about everything needing to feel good if it’s right for you. Sure, there’s a time and a place for alignment. But, growth often happens in the uncomfortable moments. Just a reminder. Keep going. ❤️

There’s so much buzz about everything needing to feel good if it’s right for you.

Sure, there’s a time and a place for alignment.

But, growth often happens in the uncomfortable moments.

Just a reminder.
Keep going.
❤️ ...

32 9

Boating! I forgot to add boating to the list 🛶

Regulation is found in the micro moments.

Which of these have you done lately?

60 8
Open
Boating! I forgot to add boating to the list 🛶 Regulation is found in the micro moments. Which of these have you done lately?

Boating! I forgot to add boating to the list 🛶

Regulation is found in the micro moments.

Which of these have you done lately? ...

60 8

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