Treatment Options: Medications in the Pipeline


New Medications in the Pipeline

For the past three weeks we have looked at the different categories of medications available for multiple sclerosis, injectable medications, oral medications and infused medications. This week we will take a look at the medications that are up-and-coming in the research pipeline. There are numerous studies going on currently, far too many to list all of them in one post, but we will look at some of the biggest studies going on right now.

Laquinimod

Laquinimod is a oral medication that is currently in phase 2 and phase 3 clinical trials. In 2014 it was refused a license for relapsing remitting MS due to poor trial results. It is now being studied for both relapsing remitting and primary progressive MS.
Laquinimod is thought to alter behavior of a me in cells and preventing them from crossing the blood brain barrier and damaging myelin. It also looks like Laquinimod can reduce inflammation and protect nerve structures and functions.
Several studies over the past few years were not promising. The drug did not reduce the relapse rate as compared to a placebo, but it did reduce rates of brain shrinkage and disability progression.

Ofatumumab

Ofatumumab is an injection or an infusion that is being researched for relapsing MS. Phase 2 trials were completed and now Phase 3 trials have begun. In these phase 3 trials the medication is injected under the skin every four weeks. Ofatumumab is an antibody and is thought to work by binding to the surface of a specific immune cell, B cells, and reduce their numbers.
In past clinical trials the results were very promising. Ofatumumab reduced relapse rates and slowed worsening of disability more effectively than Aubagio and Ofatumumab reduced new brain lesions by up to 90% as compared with placebos.

HSCT

HSCT is an intense chemotherapy treatment for multiple sclerosis, it is also known as stem cell treatment. It works by removing harmful immune cells then the individuals own stem cells are used to regrow the immune system.
There are several clinical trials that are going on using stem cell treatment for MS. Usually the individuals involved in these trials have had disease progression despite being on medication previously.
Results have been generally promising and showed that stem cell therapy has been effective at reducing relapses. Several studies also showed that stem cell therapy has been able to reduce disease progression as evidenced by improved EDSS scores.
There are over a hundred clinical trials currently going on looking for new treatments for Multiple Sclerosis and it’s related symptoms. Various studies include “Pilot study of Mirabegron and behavioral modification including pelvic floor exercise for overactive bladder in multiple sclerosis (MIRROR)” which is in Phase 4 and “A Multiple Dose Study of ABT-555 in Subjects With Relapsing Forms of Multiple Sclerosis” which is in Phase 1.
It is an exciting time in MS research. Hopefully more treatments that look at gut flora and the effects it has on MS progression will be completed soon as well!

I’M ALISSA!

I help women who have also been diagnosed with Multiple Sclerosis make specific and personalized diet, lifestyle & subconscious changes so that they can begin to heal their body, reduce disease symptoms, and return to a life they love.hey there,

follow along on Instagram:

👉🏼Feeling stuck with your MS symptoms?
👉🏼Feeling like your body betrayed you and is working against you?
👉🏼Are you worried you’re stuck like this and will never get better?

I get it. At one point I did too.

Years ago I was experiencing “Aggressive MS” and I thought I’d never function the same.

I thought my days of moving how I wanted, or doing anything on a whim were over.

I couldn’t walk well, couldn’t feel my body correctly and I was SCARED.

But now?
I’m confident in the ways I’m helping myself.
I no longer have aggressive MS.
I can move how I want, when I want.

Because of the changes I’ve made over the years.

No, it’s not easy, but that’s where I come in!!

I’ve dedicated my life to helping those with MS realize that feeling better is possible and helping them get there.

My 2 courses and my membership are on sale this weekend for Black Friday,

want to start your own success story??

Comment SUCCESS below and I’ll send you the link!!

👉🏼Feeling stuck with your MS symptoms?
👉🏼Feeling like your body betrayed you and is working against you?
👉🏼Are you worried you’re stuck like this and will never get better?

I get it. At one point I did too.

Years ago I was experiencing “Aggressive MS” and I thought I’d never function the same.

I thought my days of moving how I wanted, or doing anything on a whim were over.

I couldn’t walk well, couldn’t feel my body correctly and I was SCARED.

But now?
I’m confident in the ways I’m helping myself.
I no longer have aggressive MS.
I can move how I want, when I want.

Because of the changes I’ve made over the years.

No, it’s not easy, but that’s where I come in!!

I’ve dedicated my life to helping those with MS realize that feeling better is possible and helping them get there.

My 2 courses and my membership are on sale this weekend for Black Friday,

want to start your own success story??

Comment SUCCESS below and I’ll send you the link!!
...

14 0
Grab your path to healing!!

These are the lowest prices for my courses like ever, and they won’t be back. (And they’ll prob be going up in the new year- planning some updates!!)

Comment HEALING below and I’ll send you a link, or check out my stories!!

Grab your path to healing!!

These are the lowest prices for my courses like ever, and they won’t be back. (And they’ll prob be going up in the new year- planning some updates!!)

Comment HEALING below and I’ll send you a link, or check out my stories!!
...

3 2
The first step to being successful with managing stress (& being successful with anything really) is:

Awareness of where you currently are.

You can’t change or manage what you’re not aware of.

You can only know yourself as deep as you’re awareness of yourself goes.

Try this:
Right now as you read this, pause for a sec.
Take a deep breath, and ask yourself:

Where were my thoughts?
Where is my breathing?
What am I saying to myself?

Get really honest here too (warning- it might be uncomfy)

What did you discover while checking in? Let me know in the comments!

-
-
If we haven’t met yet, Hi! 👋🏼👋🏼 I’m Alissa. I’m a Holistic Practitioner & Therapist specializing in MS. 
I use all the tools I’ve comprised over my 10+ year career (and 14+ years with MS) to help my clients with MS decrease their symptoms, improve their overall health and get back to living life on their terms, not MS’ terms.
Interested to hear how that might look for you? Comment 🧡 below or DM me and we’ll chat!

The first step to being successful with managing stress (& being successful with anything really) is:

Awareness of where you currently are.

You can’t change or manage what you’re not aware of.

You can only know yourself as deep as you’re awareness of yourself goes.

Try this:
Right now as you read this, pause for a sec.
Take a deep breath, and ask yourself:

Where were my thoughts?
Where is my breathing?
What am I saying to myself?

Get really honest here too (warning- it might be uncomfy)

What did you discover while checking in? Let me know in the comments!

-
-
If we haven’t met yet, Hi! 👋🏼👋🏼 I’m Alissa. I’m a Holistic Practitioner & Therapist specializing in MS.
I use all the tools I’ve comprised over my 10+ year career (and 14+ years with MS) to help my clients with MS decrease their symptoms, improve their overall health and get back to living life on their terms, not MS’ terms.
Interested to hear how that might look for you? Comment 🧡 below or DM me and we’ll chat!
...

14 1
Progress is absolutely not linear.

But, it’s still progress nonetheless.

I see you if you’re in a “dip” or feel like you’re going “backwards”

You’re really not, you’re right where you should be.

Keep going!!
🧡❤️🧡

Progress is absolutely not linear.

But, it’s still progress nonetheless.

I see you if you’re in a “dip” or feel like you’re going “backwards”

You’re really not, you’re right where you should be.

Keep going!!
🧡❤️🧡
...

21 1
Lol, all this got me was an MS diagnosis. 

This was me basically my whole life up until a few years ago.

My clients have all talked about situations like this too.

It’s no wonder why a lot of us have an autoimmune disease now. 

Please, speak your truth. Your body will thank you.

If we haven’t met yet, Hi! 👋🏼👋🏼 I’m Alissa.
I’m a Holistic Practitioner & Therapist specializing in MS.

I use all the tools I’ve comprised over my 10+ year career (and 14+ years with MS) to help my clients with MS decrease their symptoms, improve their overall health and get back to living life on their terms, not MS’ terms.

Interested to hear how that might look for you? Comment 🧡 below or DM me and we’ll chat!

Lol, all this got me was an MS diagnosis.

This was me basically my whole life up until a few years ago.

My clients have all talked about situations like this too.

It’s no wonder why a lot of us have an autoimmune disease now.

Please, speak your truth. Your body will thank you.

If we haven’t met yet, Hi! 👋🏼👋🏼 I’m Alissa.
I’m a Holistic Practitioner & Therapist specializing in MS.

I use all the tools I’ve comprised over my 10+ year career (and 14+ years with MS) to help my clients with MS decrease their symptoms, improve their overall health and get back to living life on their terms, not MS’ terms.

Interested to hear how that might look for you? Comment 🧡 below or DM me and we’ll chat!
...

90 4
This has been a TOUGH week friends.

Don’t lose yourself.

What else would you add to this list?
What helps you when life is super hard?

❤️❤️

This has been a TOUGH week friends.

Don’t lose yourself.

What else would you add to this list?
What helps you when life is super hard?

❤️❤️
...

20 2
I’ve been actively working on my nervous system for the past year or two.

That hasn’t meant that all my anxiety or depression magically vanished.

It just means that when I do find myself feeling like an anxious mess or a depressed puddle, I know how to attend to and care for myself.

Not in the goal of “fixing” per se, more honoring and accepting.

This is one of the ways I help my clients improve their MS symptoms, but attending to their nervous systems and improving their stress response and resilience.

I have so many ways to work with me.. from 1:1 support to my free community.. comment below “interested” and we’ll chat about what would be right for you!

I’ve been actively working on my nervous system for the past year or two.

That hasn’t meant that all my anxiety or depression magically vanished.

It just means that when I do find myself feeling like an anxious mess or a depressed puddle, I know how to attend to and care for myself.

Not in the goal of “fixing” per se, more honoring and accepting.

This is one of the ways I help my clients improve their MS symptoms, but attending to their nervous systems and improving their stress response and resilience.

I have so many ways to work with me.. from 1:1 support to my free community.. comment below “interested” and we’ll chat about what would be right for you!
...

18 2
This is exactly why I do what I do.

Because when I was suffering and going through it, I had no one. 

No one in my corner who fully understood.

Sure I had some people around me who cared.. but that’s different than understanding and being supportive.

I don’t want that for you.

I want you to feel confident,
in control of your life,
like you have someone in your corner who understands on a completely different level than those around you.

This is why I do what I do.

Because I don’t want you to feel alone.

PS- My second book is available for pre-order!!
This is a book that I would have loved to read early on in my journey. 
I teamed up with 6 other authors to detail how we moved through our diagnosis and came out the other side for the better.
(Also, 5 of the 7 authors also have MS!!)

If you pre order your copy through me before October 24th you’ll also get:
• Signed copy of Resilience Redefined
• The MS Handbook E-book
• Resilience Bookmark
• LissMS Sticker Pack

Comment “book” below and I’ll send you the link!!

This is exactly why I do what I do.

Because when I was suffering and going through it, I had no one.

No one in my corner who fully understood.

Sure I had some people around me who cared.. but that’s different than understanding and being supportive.

I don’t want that for you.

I want you to feel confident,
in control of your life,
like you have someone in your corner who understands on a completely different level than those around you.

This is why I do what I do.

Because I don’t want you to feel alone.

PS- My second book is available for pre-order!!
This is a book that I would have loved to read early on in my journey.
I teamed up with 6 other authors to detail how we moved through our diagnosis and came out the other side for the better.
(Also, 5 of the 7 authors also have MS!!)

If you pre order your copy through me before October 24th you’ll also get:
• Signed copy of Resilience Redefined
• The MS Handbook E-book
• Resilience Bookmark
• LissMS Sticker Pack

Comment “book” below and I’ll send you the link!!
...

11 0
When this is a new habit.. it’s HARD!!

We encounter so many messages that say DONT take time for you, prioritize others, you must.

So.. what stands in your way of prioritizing you?

What is your hesitation when you go take a minute for yourself?

What is the guilt you feel after you actually do?

I’m planning something in a few weeks to help you with just these things.. stay tuned…

When this is a new habit.. it’s HARD!!

We encounter so many messages that say DONT take time for you, prioritize others, you must.

So.. what stands in your way of prioritizing you?

What is your hesitation when you go take a minute for yourself?

What is the guilt you feel after you actually do?

I’m planning something in a few weeks to help you with just these things.. stay tuned…
...

53 0
I’ve found that most all of my clients (and my past self too) would say NOPE, at least at first.

There are so many reasons we don’t value our own needs as much as others, but this is something that def has to be addressed if we want to continue to make progress with improving our health.

You matter.
Remember that.
🧡❤️

I’ve found that most all of my clients (and my past self too) would say NOPE, at least at first.

There are so many reasons we don’t value our own needs as much as others, but this is something that def has to be addressed if we want to continue to make progress with improving our health.

You matter.
Remember that.
🧡❤️
...

17 2
This is what came through during my meditation this morning.

I’ve been feeling so BEHIND lately..
That I’m not doing enough..
That progress isn’t happening fast enough..

But that’s a lie.
I’m right where I should be.

I needed this message today… maybe you do too?

This is what came through during my meditation this morning.

I’ve been feeling so BEHIND lately..
That I’m not doing enough..
That progress isn’t happening fast enough..

But that’s a lie.
I’m right where I should be.

I needed this message today… maybe you do too?
...

15 4
This is how I slowly helped myself the most:
Making small changes to my life,
* Intentional awareness to my morning
* Noticing when I’m being mean to myself 
* Noticing when I’m reactive or in a state of fight or flight..

Some “small” ideas for you too:
* don’t grab your phone first thing in the morning, take some deep breaths, think about how you want your day to go
* drink an extra glass of water (bonus if it’s in the morning too)
* get up and move every hour
* say something nice to yourself when you catch yourself being mean
* step outside for a few minutes a few times a day

Small changes add up to big steps forward,
don’t get fooled by these not being “enough”,
they absolutely are. 

Wanna hear more about how Ive helped myself and my clients to lessen our MS symptoms so we feel better in our bodies?

I detail it in my chapter in Resilience Redefined.. comment “Book” and I’ll send you the link!!

This is how I slowly helped myself the most:
Making small changes to my life,
* Intentional awareness to my morning
* Noticing when I’m being mean to myself
* Noticing when I’m reactive or in a state of fight or flight..

Some “small” ideas for you too:
* don’t grab your phone first thing in the morning, take some deep breaths, think about how you want your day to go
* drink an extra glass of water (bonus if it’s in the morning too)
* get up and move every hour
* say something nice to yourself when you catch yourself being mean
* step outside for a few minutes a few times a day

Small changes add up to big steps forward,
don’t get fooled by these not being “enough”,
they absolutely are.

Wanna hear more about how Ive helped myself and my clients to lessen our MS symptoms so we feel better in our bodies?

I detail it in my chapter in Resilience Redefined.. comment “Book” and I’ll send you the link!!
...

23 5

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